I have  already talked about the protein and why its structure is so important, and what is the different popular methods of protein structure prediction. We know that ab initio or de novo and homology modelling are most commonly used method for protein structure prediction So lets stat with ab initio or de novo protein prediction.

• Protein 3D Structure Prediction Tutorial : Part-I
• Protein 3D Structure Prediction Tutorial : Part-II

What is ab initio or de novo protein prediction
This method predict protein tertiary structures from its sequences based on common principles that control protein folding energetics and statistical tendencies of conformational features that native structures acquire

• + Points

1. You don't need template or previously solved structure
2. Theoretically you can predict the structure of almost any protein

• - Point

1. need vast computational resources and therefore only carried out for protein of relatively small size

ab initio protein structure prediction server

• Protinfo ABCM HERE
• QUARK HERE

ab initio modelling  HERE